Bioactivity:

CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.

CAS nr:

1421693-22-2

Purity:

98%

Molecular Weight:

394,45

SMILES:

CNC1=NC(C)=C(C2=C(F)C=NC(NC3=CC(S(=O)(N)=O)=CC=C3)=N2)S1

Formula:

C15H15FN6O2S2

Pathway:

Apoptosis,Cell Cycle/Checkpoint

Target:

Apoptosis,CDK