Bioactivity:

Hernandezine, a novel AMPK activator, can inhibit LPS-induced TNF_ﾱ expression/production in human macrophage cells (THP-1 and U937 lines).

CAS nr:

6681-13-6

Purity:

98%

Molecular Weight:

652,77

SMILES:

CN1CCC2=CC(=C3C=C2[C@@H]1CC4=CC=C(C=C4)OC5=C(C=CC(=C5)C[C@H]6C7=C(CCN6C)C(=C(C(=C7O3)OC)OC)OC)OC)OC

Formula:

C39H44N2O7

Pathway:

Apoptosis,Immunology/Inflammation,PI3K/Akt/mTOR signaling

Target:

TNF,ROS,AMPK