Bioactivity:

PD 158780 reversibly inhibits auto and transphosphorylation of all four members of the ErbB receptor superfamily: EGFR, ErbB2, ErbB3, and ErbB4 (IC50s: 8_M, 49 nM, 52 nM, and 52 nM in cell assay).

CAS nr:

171179-06-9

Purity:

98%

Molecular Weight:

330,19

SMILES:

CNc1cc2c(Nc3cccc(Br)c3)ncnc2cn1

Formula:

C14H12BrN5

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

EGFR,EGFR,EGFR