Bioactivity:

SKLB1028 is a new type of oral multikinase inhibitor of EGFR, FLT3, and Abl. It shows excellent activity in FLT3-driven AML models and considerable potency in CML models containing Abl mutants.

CAS nr:

1350544-93-2

Purity:

98%

Molecular Weight:

443,56

SMILES:

CN1CCN(C2=CC=C(NC3=NC=C4N=C(NC5=CC=CN=C5)N(C(C)C)C4=N3)C=C2)CC1

Formula:

C24H29N9

Pathway:

Target: