Bioactivity:

GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).

CAS nr:

2680616-96-8

Purity:

98%

Molecular Weight:

428,48

SMILES:

FC1(CCN(C2=NC(C3CCNC3)=CC(NC4=CC5=C(C=N4)C=NN5C(C)C)=N2)C1)F

Formula:

C21H26F2N8

Pathway:

MAPK,Others

Target:

MAPK,Others