Bioactivity:

Lactisole is an antagonist of sweet taste receptors, reducing both sweetness intensity and persistence. [1][2] It blocks the activation of the sweet taste receptor T1R3 by natural and synthetic sweeteners and increases the inhibition of T1R2 by umami compounds. [3][4] Lactisole can be used to explore the roles of these receptors in diverse pathways, including glucose-induced insulin secretion in pancreatic _-cells and the secretion of glucagon-like peptides by enteroendocrine L-cells. [3][5][6]

CAS nr:

150436-68-3

Purity:

98%

Molecular Weight:

218,184

SMILES:

[Na+].COc1ccc(OC(C)C([O-])=O)cc1

Formula:

C10H11NaO4

Pathway:

Metabolism

Target:

Taste receptor