Bioactivity:

AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8 and CDK19 inhibitor (IC50s: 0.61 nM and 4.28 nM). STAT5 activation enhanced by AS2863619 free

CAS nr:

2241300-50-3

Purity:

98%

Molecular Weight:

332,32

SMILES:

NC1=NON=C1C(N2C3=CC=C4N=C(C)NC4=C3)=NC5=C2C=CN=C5

Formula:

C16H12N8O

Pathway:

Cell Cycle/Checkpoint

Target:

CDK