Bioactivity:

GNF4877 is a potent DYRK1A and GSK3_ inhibitor (IC50s: 6_nM and 16_nM). It�leads to blockade of nuclear factor of activated T-cells (NFATc) nuclear export and increased _-cell proliferation cells.

CAS nr:

2041073-22-5

Purity:

98%

Molecular Weight:

494,52

SMILES:

CC(C)OC1=CC(=C(C=C1)F)C2=CN=C(C(=N2)C(=O)NC3=C(C=CN=C3)N4CCC[C@H](C4)C(=O)O)N

Formula:

C25H27FN6O4

Pathway:

Stem Cells,PI3K/Akt/mTOR signaling,Tyrosine Kinase/Adaptors,Cell Cycle/Checkpoint

Target:

GSK-3,GSK-3,DYRK,DYRK