Bioactivity:

GSK321 is an effective and selective IDH1 mutation inhibitor, which can effectively inhibit the production of 2-HG in HT-1080 cells, and induce IDH1 mutant cells to differentiate into bone marrow at the level of leukemia blasts and more stem cells.

CAS nr:

1816331-63-1

Purity:

98%

Molecular Weight:

501,56

SMILES:

O=C(C1=NN(CC2=CC=C(F)C=C2)C3=C1CN(C(C4=CC=CN4)=O)C[C@H]3C)NC5=CC=CC([C@@H](O)C)=C5

Formula:

C28H28FN5O3

Pathway:

Target: