Bioactivity:

CAL-101 is a selective inhibitor of p110_(IC50 : 2.5 nM; in cell-free assays); shown to have 40- to 300-fold greater selectivity for p110_ than p110_/_/_, and 400- to 4000-fold more selectivity to p110_ than C2_, hVPS34, DNA-PK and mTOR.

CAS nr:

1146702-54-6

Purity:

98%

Molecular Weight:

415,42

SMILES:

O=C1N(C2=CC=CC=C2)C([C@@H](NC3=C4N=CNC4=NC=N3)C)=NC5=C1C(F)=CC=C5

Formula:

C22H18FN7O

Pathway:

PI3K/Akt/mTOR signaling

Target:

PI3K