Bioactivity:

PF-4191834 is an orally active, noniron chelating, and non-redox inhibitor of the 5-Lipoxygenase (5-LOX) (IC50=229 nM). PF-4191834 shows ~300-fold selectivity for 5-LOX over 12-LOX and 15-LOX and displays no activity toward the cyclooxygenase enzymes. PF-

CAS nr:

1029317-21-2

Purity:

98%

Molecular Weight:

393,5

SMILES:

O=C(C1(C2=CC=CC(SC3=CC=C(C4=CC=NN4C)C=C3)=C2)CCOCC1)N

Formula:

C22H23N3O2S

Pathway:

Metabolism

Target:

Lipoxygenase