Bioactivity:

IQ3 is a selective inhibitor of JNK3(JNK3, JNK1 and JNK2 with Kd of 66 nM, 240 nM and 290 nM, respectively). IQ 3 inhibits NF-_B/AP1 transcriptional activity in THP1-Blue cells with IC50 of 1.4 _M, also inhibits TNF-_ and IL-6 production in vitro.

CAS nr:

312538-03-7

Purity:

98%

Molecular Weight:

341,32

SMILES:

O=C(ON=C1C2=CC=CC=C2C2=NC3=CC=CC=C3N=C12)C1=CC=CO1

Formula:

C20H11N3O3

Pathway:

MAPK

Target:

JNK