Bioactivity:

VU-29 is a positive allosteric mGlu5 receptor modulator with EC50=9 nM and Ki=244 nM for rmGluR5. It is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 _M; hmGluR4=154 nM).

CAS nr:

890764-36-0

Purity:

98%

Molecular Weight:

384,39

SMILES:

[O-][N+](=O)c1ccc(cc1)C(=O)Nc1cc(nn1-c1ccccc1)-c1ccccc1

Formula:

C22H16N4O3

Pathway:

Neuroscience

Target:

GluR