Bioactivity:

PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selectivity against other protein kinases, except for some CDKs.

CAS nr:

939791-38-5

Purity:

98%

Molecular Weight:

665,66

SMILES:

OS(=O)(=O)c1ccccc1.CN(c1c(CNc2c(cnc(Nc3ccc4NC(=O)Cc4c3)n2)C(F)(F)F)cccn1)S(=O)(=O)C

Formula:

C21H20F3N7O3S�C6H6O3S

Pathway:

Cell Cycle/Checkpoint,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

CDK,PYK2,FAK,FAK,FAK