Bioactivity:

Pyr6 is a selective TRPC3 inhibitor with IC50 of 0.49 uM(Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells).Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.

CAS nr:

245747-08-4

Purity:

98%

Molecular Weight:

418,27

SMILES:

O=C(C1=C(F)C=NC=C1)NC2=CC=C(N3N=C(C(F)(F)F)C=C3C(F)(F)F)C=C2

Formula:

C17H9F7N4O

Pathway:

Membrane transporter/Ion channel

Target:

TRP/TRPV Channel