Bioactivity:

XL177A is a selective irreversible USP7 inhibitor(IC50 : 0.34_nM). XL177A elicits cancer cell killing through a p53-dependent mechanism.

CAS nr:

2417089-74-6

Purity:

98%

Molecular Weight:

861,47

SMILES:

O=C(NC1=CC(N=CN2CC3(O)CCN(C([C@H](CC4=CC=CC=C4)CCCNC(C5=CC(N=C(CCCC6)C6=C7Cl)=C7C=C5)=O)=O)CC3)=C(C=C1)C2=O)CCN8CCN(C)CC8

Formula:

C48H57ClN8O5

Pathway:

Ubiquitination,Cell Cycle/Checkpoint,DNA Damage/DNA Repair

Target:

DUB,DUB,DUB