Bioactivity:

Allitinib (AST-1306) is an orally active and irreversible EGFR and ErbB2 inhibitor with IC50s of 0.5 and 3 nM, respectively. Allitinib is an anilino-quinazoline compound and has anti-cancer activity[1]. Allitinib also inhibits ErbB4 with an IC50 of 0.8 nM

CAS nr:

897383-62-9

Purity:

98%

Molecular Weight:

448,88

SMILES:

FC1=CC=CC(COC2=C(Cl)C=C(NC3=NC=NC4=C3C=C(NC(C=C)=O)C=C4)C=C2)=C1

Formula:

C24H18ClFN4O2

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

EGFR,EGFR,EGFR