Bioactivity:

JAK 3 inhibitor IV is a JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.

CAS nr:

58753-54-1

Purity:

98%

Molecular Weight:

241,33

SMILES:

O=C(C1=CC=C2C=CC=CC2=C1)CCNC(C)C

Formula:

C16H19NO

Pathway:

JAK/STAT signaling,Chromatin/Epigenetic,Stem Cells,Angiogenesis,Others,Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

JAK,JAK,JAK,JAK,Others,EGFR,EGFR,EGFR