Bioactivity:

Pexmetinib (ARRY-614) is a potent, orally bioavailable, dual p38 MAPK/Tie-2 inhibitor with IC50 of 4 nM/18 nM in a HEK-293 cell line. Phase 1.

CAS nr:

945614-12-0

Purity:

98%

Molecular Weight:

556,63

SMILES:

Cc1ccc(cc1)-n1nc(cc1NC(=O)NCc1cc(F)ccc1Oc1ccc2n(CCO)ncc2c1)C(C)(C)C

Formula:

C31H33FN6O3

Pathway:

Tyrosine Kinase/Adaptors,Autophagy,MAPK

Target:

Tie-2,Autophagy,p38 MAPK