Bioactivity:

AG-490 (Tyrphostin AG 490) is an inhibitor of EGFR (IC50: 0.1 _M). It is 135-fold more selective for EGFR than ErbB2, also inhibits JAK2 with no effect to Lyn, Lck, Syk, Btk, and Src.

CAS nr:

133550-30-8

Purity:

98%

Molecular Weight:

294,3

SMILES:

C1=CC=C(C=C1)CNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N

Formula:

C17H14N2O3

Pathway:

Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic,JAK/STAT signaling,Stem Cells,Stem Cells,Autophagy,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling

Target:

JAK,JAK,JAK,STAT,JAK,STAT,Autophagy,EGFR,EGFR,EGFR