Bioactivity:

CBL0137, a metabolically stable curaxin, activates p53 (EC50: 0.37 _M) and inhibits NF-_B (EC50: 0.47 _M). It functionally inactivates the facilitates chromatin transcription complex (FACT), driving the effects on p53 and NF-_B and promoting cancer cell d

CAS nr:

1197996-80-7

Purity:

98%

Molecular Weight:

336,44

SMILES:

CC(C)NCCn1c2c(cc(cc2)C(=O)C)c2c1ccc(c2)C(=O)C

Formula:

C21H24N2O2

Pathway:

NF-_b,Apoptosis

Target:

NF-_B,p53