Bioactivity:

GKI-1 robustly inhibits ROCK1 with an IC50 of 11 �M, but only weakly affected PKA.�GKI-1 is a Greatwall (GWL) kinase inhibitor with IC50s of 4.9 and 2.5 �M against hGWLFL and hGWL-KinDom, respectively.

CAS nr:

T11402

Purity:

98%

Molecular Weight:

269,73

SMILES:

ClC(C=C1)=CC=C1NC2=CC(C3=CNN=C3)=CC=C2

Formula:

C15H12ClN3

Pathway:

Others

Target:

Others