Bioactivity:

AP26113 is a potent ALK inhibitor with IC50 of 0.62 nM in a cell-free assay, demonstrated ability overcome Crizotinib resistance mediated by a L1196M mutation. Phase 2.

CAS nr:

1197958-12-5

Purity:

98%

Molecular Weight:

529,01

SMILES:

COc1c(Nc2ncc(Cl)c(Nc3ccccc3P(=O)(C)C)n2)ccc(c1)N1CCC(CC1)N(C)C

Formula:

C26H34ClN6O2P

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

ALK,ALK,EGFR,EGFR,EGFR,IGF-1R