Bioactivity:

Bisindolylmaleimide VIII acetate is a potent and selective PKC inhibitor (IC50: 158 nM for rat brain PKC). It has IC50s of 53, 195, 163, 213, and 175 nM for PKC-_, PKC-_I, PKC-_II, PKC-_, PKC-_, respectively.

CAS nr:

138516-31-1

Purity:

98%

Molecular Weight:

458,51

SMILES:

O=C(C(C1=CN(CCCN)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC=C5)NC3=O.CC(O)=O

Formula:

C26H26N4O4

Pathway:

Apoptosis,Cytoskeletal Signaling,Chromatin/Epigenetic

Target:

Apoptosis,PKC,PKC