Bioactivity:

PLX7904, also known as PB04, is a potent and selective paradox-breaker RAF inhibitor. It is able to efficiently inhibit activation of ERK1/2 in mutant BRAF melanoma cells but does not hyperactivate ERK1/2 in mutant RAS-expressing cells.

CAS nr:

1393465-84-3

Purity:

98%

Molecular Weight:

512,53

SMILES:

CCN(C)S(=O)(=O)NC1=CC=C(F)C(C(=O)C2=CNC3=NC=C(C=C23)C2=CN=C(N=C2)C2CC2)=C1F

Formula:

C24H22F2N6O3S

Pathway:

MAPK

Target:

Raf