Bioactivity:

AMG-548 hydrochloride is an orally active and selective p38_ inhibitor (Ki: 0.5 nM) and shows slightly selective over p38_ (Ki: 36 nM) and >1000 fold selective against p38_/p38_. It is also extremely potent in the inhibition of whole blood LPS stimulated

CAS nr:

T10298

Purity:

98%

Molecular Weight:

498,02

SMILES:

O=C1N(C)C(NCC(N)CC2=CC=CC=C2)=NC(C3=CC=NC=C3)=C1C4=CC=C5C=CC=CC5=C4.Cl

Formula:

C29H28ClN5O

Pathway:

MAPK

Target:

p38 MAPK