Bioactivity:

PF-04859989 is a brain-penetrable irreversible inhibitor of kynurenine amino transferase II. PF-04859989 is ~1000-fold selective for KAT II over human KAT I, KAT III, and KAT IV. PF-04859989 has IC50 values of 23 nM for hKAT II and 263 nM for rKAT II.

CAS nr:

34783-48-7

Purity:

98%

Molecular Weight:

178,19

SMILES:

ON(C1=CC=CC=C1C[C@@H]2N)C2=O

Formula:

C9H10N2O2

Pathway:

Target: