Bioactivity:

Agerafenib hydrochloride is a highly potent inhibitor of BRAFV600E (Kd: 14 nM).

CAS nr:

1227678-26-3

Purity:

98%

Molecular Weight:

553,92

SMILES:

O=C(NC1=NOC(C(C)(C)C(F)(F)F)=C1)NC2=CC=CC(OC3=C(C=C(OC)C(OC)=C4)C4=NC=N3)=C2.[H]Cl

Formula:

C24H23ClF3N5O5

Pathway:

Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Apoptosis

Target:

c-Kit,c-RET,c-RET