Bioactivity:

PF-03715455 potently inhibits LPS-induced TNF_ production in human whole blood (IC50=1.7 nM). PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38_ over p38_ (respective IC50: 0.88 and 23 nM). PF-0371545

CAS nr:

1056164-52-3

Purity:

98%

Molecular Weight:

700,27

SMILES:

CC(C)(C1=NN(C2=CC=C(O)C(Cl)=C2)C(NC(NCC3=CC=CC=C3SC4=CN5C(C6=CC=CC=C6SCCO)=NN=C5C=C4)=O)=C1)C

Formula:

C35H34ClN7O3S2

Pathway:

MAPK

Target:

p38 MAPK