Bioactivity:

MRTX849 is a potent, selective and covalent KRASG12C inhibitor with potential antineoplastic activity. It selectively modifies mutant cysteine 12 in GDP-bound KRASG12C, and inhibits KRAS-dependent signaling.

CAS nr:

2326521-71-3

Purity:

98%

Molecular Weight:

604,12

SMILES:

CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12

Formula:

C32H35ClFN7O2

Pathway:

MAPK,GPCR/G Protein

Target:

Ras,Ras