Bioactivity:

IDH-305 is an orally available, mutant-selective and brain-penetrant IDH1 inhibitor. IDH-305 shows greater than 200 fold selectivity for mutant IDH1 isoforms vs. WT (IC50s: 27 nM (IDH1R132H), 28 nM (IDH1R132C), 6.14 ﾵM (IDH1WT)).

CAS nr:

1628805-46-8

Purity:

98%

Molecular Weight:

490,45

SMILES:

O=C1OC[C@H]([C@@H](F)C)N1C2=NC(N[C@H](C3=CC(C)=C(C4=CC(C(F)(F)F)=NC=C4)C=N3)C)=NC=C2

Formula:

C23H22F4N6O2

Pathway:

Metabolism

Target:

Dehydrogenase