Bioactivity:

VU0486321 is a potent mGlu1 PAM with moderate rat PK (CLp = 13.3. mL/min/kg,t1/2 = 54 min), good free fraction (human fu = 0.05, rat fu =0.03) and excellent CNS penetration (Kp = 1.02).

CAS nr:

1816301-67-3

Purity:

98%

Molecular Weight:

398,77

SMILES:

FC1=C2C(C(N(C3=CC=C(NC(C4=C(C)C=CO4)=O)C=C3Cl)C2=O)=O)=CC=C1

Formula:

C20H12ClFN2O4

Pathway:

Target: