Bioactivity:

SJF_ is a 13-atom linker PROTAC. SJF_ degrades p38_ with a DC50 of 7.16__nM, but is far less effective at degrading p38_ (DC50=299_nM) and does not degrade the other p38 isoforms (_ and _) at concentrations up to 2.5_ﾵM[1].

CAS nr:

2254609-27-1

Purity:

98%

Molecular Weight:

1120,27

SMILES:

FC1=CC=C(NC(C2(CC2)C(NC3=CC(F)=C(OC4=C(C=C(OC)C(OCCCCOCCCCOCC(N[C@@H](C(C)(C)C)C(N5[C@H](C(NCC6=CC=C(C7=C(C)N=CS7)C=C6)=O)C[C@@H](O)C5)=O)=O)=C8)C8=NC=C4)C=C3)=O)=O)C=C1

Formula:

C59H67F2N7O11S

Pathway:

Others

Target:

Others