Bioactivity:

TAS05567 is a potent, highly selective, and ATP-competitive Syk inhibitor (IC50: 0.37 nM). TAS05567 only shows >70% inhibition of Syk and 4 other kinases (FLT3, JAK2, KDR, and RET with IC50s of 10 nM, 4.8 nM, 600 nM, and 29 nM, respectively) in a panel of

CAS nr:

1429038-15-2

Purity:

98%

Molecular Weight:

439,51

SMILES:

O=C(C1=C(NC2=CC3=CN(C(C)(C)C)N=C3C(C)=C2)N=C(N[C@H]4[C@@H](N)COCC4)N=N1)N

Formula:

C21H29N9O2

Pathway:

Angiogenesis,Tyrosine Kinase/Adaptors,Apoptosis,Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Stem Cells,Angiogenesis,JAK/STAT signaling,Chromatin/Epigenetic

Target:

FLT,FLT,c-RET,c-RET,Syk,Syk,JAK,JAK,JAK,JAK