Bioactivity:

TAK-243 is a small molecule inhibitor of ubiquitin-activating enzyme (UAE ,IC50=1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) st

CAS nr:

1450833-55-2

Purity:

98%

Molecular Weight:

519,52

SMILES:

O=S(OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](NC2=CC=NC3=CC(C4=CC=CC(SC(F)(F)F)=C4)=NN23)C1)(N)=O

Formula:

C19H20F3N5O5S2

Pathway:

NF-_b,Ubiquitination,Apoptosis

Target:

NF-_B,E1/E2/E3 Enzyme,Apoptosis