Bioactivity:

Tolebrutinib is a potent, selective, orally active and brain-penetrant Bruton tyrosine kinase (BTK) inhibitor(IC50s of 0.4 and 0.7 nM in Ramos B cells and in HMC microglia cells, respectively). It exhibits efficacy in central nervous system immunity. Tole

CAS nr:

1971920-73-6

Purity:

98%

Molecular Weight:

455,51

SMILES:

C=CC(N(CCC1)C[C@@H]1N(c(ccnc1N)c1N1c(cc2)ccc2Oc2ccccc2)C1=O)=O

Formula:

C26H25N5O3

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis

Target:

BTK,BTK