Bioactivity:

FM26 has a distinct isoxazole chemotype and effectively reduces IL-17a mRNA production in EL4 cells.�FM26 �is a potent and allosteric retinoic acid receptor-related orphan receptor _t (ROR_t) inverse agonists with an IC50 of 264 nM.

CAS nr:

2407981-35-3

Purity:

98%

Molecular Weight:

461,82

SMILES:

O=C(O)C1=CC=C(NCC2=C(C3=CNC=C3)ON=C2C4=C(C(F)(F)F)C=CC=C4Cl)C=C1

Formula:

C22H15ClF3N3O3

Pathway:

Metabolism

Target:

ROR