Bioactivity:

EGFR-IN-1 hydrochloride displays strong antiproliferative activity against the H1975 cells and the first line mutant HCC827 cells.�Antitumor activity.�EGFR-IN-1 hydrochloride is an orally active and irreversible L858R/T790M mutant selective EGFR inhibitor

CAS nr:

2227455-78-7

Purity:

98%

Molecular Weight:

551,04

SMILES:

COC(C=C(OCCN(C)C)C=C1)=C1NC2=NC=C3C(N(C4=CC=CC(NC(C=C)=O)=C4)C(C=C3C)=O)=N2.[H]Cl

Formula:

C28H31ClN6O4

Pathway:

Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

EGFR,EGFR,EGFR