Bioactivity:

Naquotinib (ASP8273) is an orally available, mutant-selective and irreversible EGFR inhibitor; (IC50s: 8-33 nM and 230 nM toward EGFR mutants and EGFR.

CAS nr:

1448232-80-1

Purity:

98%

Molecular Weight:

562,71

SMILES:

O=C(C1=NC(CC)=C(O[C@]2CN(C(C=C)=O)CC2)N=C1NC3=CC=C(N4CCC(N5CCN(C)CC5)CC4)C=C3)N

Formula:

C30H41N8O3

Pathway:

Angiogenesis,JAK/STAT signaling,Tyrosine Kinase/Adaptors

Target:

EGFR,EGFR,EGFR