Bioactivity:

Clofarabinem, a second generation purine nucleoside analog with antineoplastic activity, inhibits the enzymatic activities of ribonucleotide reductase (IC50 = 65 nM) and DNA polymerase.

CAS nr:

123318-82-1

Purity:

98%

Molecular Weight:

303,68

SMILES:

Nc1nc(Cl)nc2n(cnc12)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F

Formula:

C10H11ClFN5O3

Pathway:

Cell Cycle/Checkpoint,DNA Damage/DNA Repair,Autophagy,Apoptosis,DNA Damage/DNA Repair,Cell Cycle/Checkpoint

Target:

Nucleoside Antimetabolite/Analog,Nucleoside Antimetabolite/Analog,Autophagy,Apoptosis,DNA/RNA Synthesis,DNA/RNA Synthesis