Bioactivity:

Trabectedin a tetrahydroisoquinoline alkaloid. Trabectedin binds to the minor groove of DNA, blocks transcription of stress-induced proteins, induces DNA backbone cleavage and cancer cells apoptosis, and increases the generation of ROS in MCF-7 and MDA-MB

CAS nr:

114899-77-3

Purity:

98%

Molecular Weight:

761,84

SMILES:

CC1=C(OCO2)C2=C([C@H](COC3=O)N4[C@]([C@@H]5SC[C@]63C(C=C(OC)C(O)=C7)=C7CCN6)([H])[C@@H]8N(C)[C@@H](CC9=CC(C)=C(OC)C(O)=C98)[C@@H]4O)C5=C1OC(C)=O

Formula:

C39H43N3O11S

Pathway:

NF-_b,Metabolism,Immunology/Inflammation,Apoptosis

Target:

Reactive Oxygen Species,Reactive Oxygen Species,Reactive Oxygen Species,Apoptosis