Bioactivity:

JNK-IN-8 is an irreversible JNK1/2/4 inhibitor (IC50: 4.7/18.7/1 nM). The selectivity is higher 10-fold than MNK2, Fms and no inhibition of Met, c-Kit, PDGFR_ in A375 cell line.

CAS nr:

1410880-22-6

Purity:

98%

Molecular Weight:

507,59

SMILES:

Cc1c(ccc(c1)NC(=O)c1cc(ccc1)NC(=O)/C=C/CN(C)C)Nc1nccc(n1)c1cnccc1

Formula:

C29H29N7O2

Pathway:

Tyrosine Kinase/Adaptors,MAPK

Target:

c-Kit,JNK