Bioactivity:

ON-01910 is a non-ATP-competitive PLK1 inhibitor(IC50 of 9 nM, in a cell-free assay).�It shows 30-fold greater selectivity against Plk2 and no activity to Plk3.�Rigosertib inhibits PI3K/Akt pathway and activates oxidative stress signals.�Rigosertib induce

CAS nr:

1225497-78-8

Purity:

98%

Molecular Weight:

473,47

SMILES:

[Na+].COc1cc(OC)c(\C=C\S(=O)(=O)Cc2ccc(OC)c(NCC([O-])=O)c2)c(OC)c1

Formula:

C21H24NNaO8S

Pathway:

Cell Cycle/Checkpoint

Target:

PLK