Bioactivity:

AT7867 is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively; little activity outside the AGC kinase family.

CAS nr:

857531-00-1

Purity:

98%

Molecular Weight:

337,85

SMILES:

ClC1=CC=C(C=C1)C1(CCNCC1)C1=CC=C(C=C1)C1=CNN=C1

Formula:

C20H20ClN3

Pathway:

Tyrosine Kinase/Adaptors,Cytoskeletal Signaling,PI3K/Akt/mTOR signaling,MAPK,PI3K/Akt/mTOR signaling

Target:

PKA,Akt,Akt,S6 Kinase,S6 Kinase