Bioactivity:

2'-O-Methylcytidine is a nucleoside derivative and an inhibitor of hepatitis C virus (HCV) non-structural protein 5B (NS5B; IC50= 3.8 _M).1It inhibits HCV replication in a replicon assay (IC50= 21.2 _M). 1.Migliaccio, G., Tomassini, J.E., Carroll, S.S., et al.Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitroJ. Bio. Chem.278(49)49164-49170(2003)

CAS nr:

2140-72-9

Purity:

Molecular Weight:

257,246

SMILES:

CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1n1ccc(N)nc1=O

Formula:

C10H15N3O5

Pathway:

Microbiology/Virology,Proteases/Proteasome,Cell Cycle/Checkpoint,DNA Damage/DNA Repair

Target:

HCV Protease,HCV Protease,Nucleoside Antimetabolite/Analog,Nucleoside Antimetabolite/Analog