Bioactivity:

AMG PERK 44 is an orally active and selective PERK inhibitor (IC50: 6 nM) and induces autophagy. It has 1000-fold and 160-fold selectivity over GCN2 (IC50: 7300 nM) and B-Raf (IC50 >1000 nM), respectively.

CAS nr:

1883548-84-2

Purity:

98%

Molecular Weight:

561,07

SMILES:

O=C1N(C2=CC=CC=C2)N(C)C(C3=CC=CC=C3)=C1C(C4=CC=C(C)C(C5=CC=C6N=C(C)C=CC6=C5)=C4N)=O.[H]Cl

Formula:

C34H29ClN4O2

Pathway:

MAPK

Target:

ERK