Bioactivity:

JNJ-63576253 is a potent and orally active full antagonist of androgen receptor (AR), with IC50s of 37 and 54 nM for F877L mutant AR and wild-type AR in LNCaP cells.�JNJ-63576253 can be used for the research of castration-resistant prostate cancer (CRPC).

CAS nr:

2110426-27-0

Purity:

98%

Molecular Weight:

502,51

SMILES:

C1CC2(C1)C(=O)N(C(=S)N2C3=CN=C(C=C3)OC4CCNCC4)C5=CC(=C(N=C5)C#N)C(F)(F)F

Formula:

C23H21F3N6O2S

Pathway:

Endocrinology/Hormones

Target:

Androgen Receptor