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5-(N,N-Hexamethylene)-amiloride T4699

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Specifications

size	1mg/5mg/10mg/25mg/50mg/100mg

Bioactivity:

HMA is an amiloride derivative, shown to inhibit TRPA1-mediated calcium signal (IC50: 35 ﾵM). It is an inhibitor of the Na+/H+ exchanger (NHE), with Ki of 0.013-2.4 ﾵM for various NHE isoforms. HMA also blocks ASIC3 channels by 51% at 20 ﾵM.

CAS nr:

1428-95-1

Purity:

98%

Molecular Weight:

311,77

SMILES:

NC(=N)NC(=O)c1nc(Cl)c(nc1N)N1CCCCCC1

Formula:

C12H18ClN7O

Pathway:

Microbiology/Virology,Proteases/Proteasome,Others,Neuroscience,Membrane transporter/Ion channel,Apoptosis,Membrane transporter/Ion channel

Target:

HIV Protease,HIV Protease,Others,P2 Receptor,TRP/TRPV Channel,Apoptosis,Sodium Channel