Bioactivity:

Amsilarotene inhibits the phosphorylation of retinoblastoma gene product (RB) and increases the presence of 2 cyclin-dependent kinases (CDK) inhibitors resulting in cell cycle arrest. This agent also causes a cytotoxic decline in the thymidylate synthase

CAS nr:

125973-56-0

Purity:

98%

Molecular Weight:

385,6

SMILES:

O=C(O)C1=CC=C(NC(C2=CC([Si](C)(C)C)=CC([Si](C)(C)C)=C2)=O)C=C1

Formula:

C20H27NO3Si2

Pathway:

Cell Cycle/Checkpoint

Target:

CDK