Bioactivity:

PHA-665752 is an effective, specific and ATP-competitive c-Met inhibitor (IC50: 9 nM), >50-fold selectivity for c-Met than STKs or RTKs.

CAS nr:

477575-56-7

Purity:

98%

Molecular Weight:

641,61

SMILES:

Cc1c([nH]c(c1C(=O)N1CCC[C@@H]1CN1CCCC1)C)/C=C\1/c2c(ccc(c2)S(=O)(=O)Cc2c(cccc2Cl)Cl)NC1=O

Formula:

C32H34Cl2N4O4S

Pathway:

Tyrosine Kinase/Adaptors,Angiogenesis,Tyrosine Kinase/Adaptors,Tyrosine Kinase/Adaptors,Angiogenesis,Autophagy,Apoptosis,Angiogenesis,Tyrosine Kinase/Adaptors,Cytoskeletal Signaling

Target:

c-Met/HGFR,VEGFR,VEGFR,FGFR,FGFR,Autophagy,Apoptosis,Bcr-Abl,Bcr-Abl,Bcr-Abl